21c Museum Hotel Louisville

21c Museum Hotel Louisville is a gay-friendly boutique hotel and contemporary art museum in Downtown Louisville, set on Museum Row just steps from the Kentucky Center for the Performing Arts and Louisville Glassworks. With 91 rooms and a 24-hour reception, it blends hospitality with a constantly rotating exhibition space inside the building itself.

Rooms are modern and design-led, featuring free Wi-Fi, 42-inch HDTVs, Nespresso machines, and designer toiletries. Upgraded categories include semi-private rooftop terraces, while suites add separate sitting areas and dining tables. The rooftop apartment offers a full kitchen and private garden terrace for longer stays.

Facilities include a fitness center with sauna and steam room, massage treatments, valet parking, a business center, and a gift shop. It's also, of course, home to Proof on Main. The property is fully wheelchair accessible and certified for meeting ecological standards.